http://textbookofbacteriology.net/themicrobialworld/bactresanti.html |
One look at even an instructional website for laymen like me
shows the daunting complexity of the biomolecular processes at work in what looks
like a fight of good against evil in a science fiction movie. See, e.g. see
a previous post on the
engineering miracle of a bacterium. In
particular it needs to be born in mind that when healthy or hostile bacteria
(germs) mutate they do not do so at random but in a way which is structured
in both time and space. The mutation process responds to the situation, such as
a threat, and occurs only in selected parts of the genome – i.e. parts of the
bacterial genome which are involved in essential functions like reproduction do
not mutate. See, e.g., this research from the Francis Crick Institute in Cambridge.
The germs also only attack when they reach a critical
number. They know when this number is reached by communicating via signalling molecules
called autoinducers, and this process is known as quorum sensing. If potentially harmful bacteria get wrong data they don’t attack at the right
time. So if the signalling between germs could be confused or disrupted this would render them harmless and this strategy is being explored.
Knowing little about biology I am nevertheless puzzled by
the apparent absence of antibiotic research based on the recent discovery of
bacteria totally isolated for millions of years in an underground cave. It
suggests the possibility that there are bacteria in nature already resistant to
all antibiotics we are likely to develop in future.
In a way this does not seems surprising. The medicines used against harmful bacteria are all from a natural world that has been around for many millions of years. Could it be that the research on combating germs should widen its scope to consider not just systematic mutations by bacteria but the possibility that resistant strains might well be propagating around the world through winds, ocean currents, animal movements and human travel, and that whenever a new antibiotic is launched into the environment it will eventually encounter such a germ, and this germ would then be at an advantage over those still being killed by the antibiotic.
Recently I learned that it is very likely that bacteria permeate not only the biosphere but the Earth's crust, down to several miles. Could this be another means by which bacteria spread around the planet? There is also evidence of soil bacteria being resistant to penicillin. Some scientists suspect that bacteria are embedded in extra-terrestrial debris, such as comets and meteors, along with viruses, but this does not seem to have become mainstream science since the idea was pioneered by Fred Hoyle et al in the 1970s.
In a way this does not seems surprising. The medicines used against harmful bacteria are all from a natural world that has been around for many millions of years. Could it be that the research on combating germs should widen its scope to consider not just systematic mutations by bacteria but the possibility that resistant strains might well be propagating around the world through winds, ocean currents, animal movements and human travel, and that whenever a new antibiotic is launched into the environment it will eventually encounter such a germ, and this germ would then be at an advantage over those still being killed by the antibiotic.
Recently I learned that it is very likely that bacteria permeate not only the biosphere but the Earth's crust, down to several miles. Could this be another means by which bacteria spread around the planet? There is also evidence of soil bacteria being resistant to penicillin. Some scientists suspect that bacteria are embedded in extra-terrestrial debris, such as comets and meteors, along with viruses, but this does not seem to have become mainstream science since the idea was pioneered by Fred Hoyle et al in the 1970s.
Whatever direction is taken by antibiotic research it is
now recognised that the way it is funded, developed for use and dispensed to
the public needs to be radically revised. There are several promising
antibiotics that are now at a dead end because no pharmaceutical company is
prepared to take on the huge expense and risk of testing them and getting them
though the regulatory hurdles erected by governments in response to demands
from the general population and the medical profession, amplified by the media,
for ever higher safety standards. Perhaps the research could be done by
universities and non-profit philanthropic organisations, with the government
issuing prizes to the groups which come up with the best solutions. The
bringing to market of the medicines could be done separately on a contract
basis with funding by governments and international charities.
Returning to the actual front line battle against germs one
solution that has been gaining ground slowly over the decades is the use of
bacteriophages. These are viruses which eat germs and were pioneered in the USSR
before the Soviet break-up. Success has been achieved in curing certain minor
infections but this approach could conceivably lead to big breakthroughs.
Hopefully, the dark memory of a world before penicillin and
other antibiotics will be enough to shock us into doing what it takes to get
new drugs into use and more prudent ways of dispensing them.
Reach me at cosmik.jo@gmail.com